Plugging Fentanyl Patch Mylan
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Sep 21, 2013 These mallinckrodt have a bit more fentanyl. I prefer the mylan. And i cut a square about 1/10th of the patch (I was being cautious because plugging is. Detailed Fentanyl dosage information for adults and children. -Do not begin a patient on a fentanyl transdermal patch as their first opioid.
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Frumious Bandersnatch
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Is commonly used to treat Cancer patients and chronic breakthrough pain as well as pre-procedure in a hospital setting, Fentanyl is a synthetic primary μ-opioid. It’s approximately 100 times more potent than morphine; 100 micrograms of fentanyl is approx. equivalent to 10mg of morphine in analgesic activity.
Bio-Availability of Fentanyl
Fentanyl's half life averages between 3-12 hours
IV - 100%
Transdermal - ~92%
Buccal/transmucosal - 50%
Smoking - ? (it's efficient but wasteful)
info on buccal fentanyl from this article
Popular brands of Fentanyl include Actiq, Durogesic, Duragesic, Fentora, Onsolis, Sublimaze and Instanyl. Generics of the transdermal patches include Mylan, Watson and Sandoz.
Fentanyl was first synthesized by Dr. Paul Janssen in 1960 following the medical inception of meperidine several years earlier. Janssen developed fentanyl by assaying analogues of the structurally-related drug meperidine for its opioid activity. The widespread use of fentanyl triggered the production of fentanyl citrate (fentanyl combined with citrate at a 1:1 ratio), which entered the clinical practice as a general anaesthetic under the trade name Sublimaze in the 1960s. Following this, many other fentanyl analogs were developed and introduced into the medical practice, including Sufentanil, Alfentanil, Remifentanil, and Lofentanil.
In the mid 1990s, fentanyl saw its first widespread palliative use with the clinical introduction of the Duragesic patch, followed in the next decade by the introduction of the first quick-acting prescription formations of fentanyl for personal use, the Actiq lollipop and Fentora buccal tablets. Through the delivery method of transdermal patches, fentanyl is currently the most widely used synthetic opioid in clinical practice, with several new delivery methods currently in development. Fentanyl is classified as a Schedule II drug in the United States due to its potential for abuse.[1]
What’s a normal Dose?
Mylan Fentanyl Patch Abuse
In regards to Pain Management and Polymer Matrix Transdermal Patches, Fentanyl should not be applied to a patient unless having been on an opiate schedule that is equivalent to 14 days use at 60mg of oral morphine per day, which is equivalent to 40mg of oxy - check this converter. The patient is started out on the lowest dose patch, 12mcg/hr, titrating up every 24 hours until stable. Long term patients are generally safe to begin on 25mcg patches.For “fun” Fentanyl should be approached with great caution, especially to the opiate naïve who wish to indulge – this applies to all methods of administration; transdermal, smoking, IVing, bucally. I will spare the whole “you shouldn’t be fucking with fentanyl” because in the end it is up to the user in the end. The warnings are out there. But I’m just going to declare I wouldn’t advise anyone with a tolerance that is less than, say around, 120mg oral oxy, single dose, to be using this drug any other way than it is intended.
Using the 120mg oral oxy tolerance as a guide, here are my recommendations for dosing for transdermal and buccal Fentanyl. Remember I’m talking the Polymer Matrix ones here, not the Gels or lollypops as I have no experience with them. If someone can give me some reliable information for an IV and smoking dose I’ll add them in as well.
- Buccal – Start off with cutting the equivalent to 6mcg/hr, so ½ of a 12mcg patch. Place it up against your cheek, avoiding swallowing your saliva, lightly sucking in your cheeks in to apply pressure to it. Make sure it’s the actual sticky adhesive part against your cheek, that’s where the drug is stored after all.
The buccal route has a much faster absorption rate than transdermal, so expect the initial effects to be present around the 15-20min mark, peaking around 60-90mins. If you start to feel uneasy or overwhelmed at any point in time, take the patch out immediately. - Transdermal – Before you go applying anything make sure you have a good 24 hours set aside for when you do this because the patch takes around 12 hours to reach peak levels. Apply 12mcg/hr to your upper body, preferably on the upper bicep, chest area or on your shoulders. The closer to your heart the better as there’s less blood flow on your extremities. Increase your dose up according to how you feel, adding no more than 12mcg/hr at a time.
It’s difficult to gauge a good transdermal dose to begin with because of the time it takes for the Fentanyl to reach its full effects, but this doesn’t mean go crazy and think you can handle 50mcg/hr straight up. Be patient and titrate up accordingly. You may “waste” a few patches initially but your life is priceless.
Length of Effects
IV - ~1 hour
Buccal - ~2 - 4 hours of the full effects until is starts to dissipate
Smoking - ~30min - an hour
Mylan Fentanyl Patch Covers
Transdermal -72 hours
Fentanyl Threads of Interest
Is Fentanyl Safe for a Non-Tolerant user?
Mylan Fentanyl Patch Package Insert
Fentanyl Dosage Converter
Fentanyl Generics
Extracting Fentanyl from Polymer Matrix Patches
How long does Buccal Fentanyl last?
About to go through Fentanyl Withdrawal - tips
How to PLUG FENTANYL
feel free to throw out corrections. also ideas as to what should be added would be great as well. thought i would get this out there at least so we can start compiling everything in here and come up with a good end product